Short-term studies in humans report loss of muscle mass and strength and reduced bone mineral density. This is to be expected as part of the weight loss that accompanies CR. Beyond using lean tissue a ...
The long-term effects of moderate CR with adequate intake of nutrients on humans are still unknown. However, severe or extreme CR may result in serious deleterious effects, as it has been shown in the ...
In 1934, Mary Crowell and Clive McCay of Cornell University observed that laboratory rats fed a severely reduced calorie diet while maintaining micronutrient levels resulted in life spans of up to twi ...
In 2004, Fontana et al. published data from a study of 18 individuals who had been on CR for an average of 6 years and 18 age-matched healthy individuals on typical American diets. The study took one ...
Long-term CR in humans results in a reduction of several metabolic and hormonal factors that have been associated with increased risk of some of the most common type of cancer in developed countries. ...
Caloric restriction (CR), or calorie restriction, is a dietary regimen that is based on low calorie intake. "Low" can be defined relative to the subject's previous intake before intentionally restrict ...
