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Antiquity 2600 BC – Imhotep the priest-physician who was later deified as the Egyptian god of medicine.[1]ancient Egyptian medicine 2500 BC - Iry Egyptian inscription speaks of Iry as [eye-doctor of the palace,] [palace physician of the belly,] [guardian of the royal bowels,] and [he who prepares the important medicine (name cannot be translated) and knows the inner juices of the body.][2] 1900 BC - 1600 BC Akkadian clay tablets on medicine survive primarily as copies from Ashurbanipal's library at Nineveh.[3] 1800 BC - Code of Hammurabi sets out fees for surgeons and punishments for malpractice[2] 1800 BC - Kahun Gynecological Papyrus 1600 BC - Hearst papyrus 1551 BC - Ebers Papyrus 1500 BC – Saffron used as a medicine on the Aegean island of Thera in ancient Greece 1500 BC - Edwin Smith Papyrus an Egyptian medical text and the oldest known surgical treatise (no true surgery)[2] 1300 BC - Brugsch Papyrus and London Medical Papyrus 1250 BC - Asklepios[2] 9th century- Hesiod reports an ontological conception of disease via the Pandora myth. Disease has a "life" of its own but is of devine origin.[4] 8th century - Homer tells that Polydamna supplied the Greek forces besieging Troy with healing drugs Homer also tells about battlefield surgery Idomeneus tells Nestor after Machaon had fallen: A surgeon who can cut out an arrow and heal the wound with his ointments is worth a regiment.[2] 700 BC - Cnidos medical school also one at Cos 500 BC - Darius I orders the restoration of the House of Life (First record of a (much older) medical school)[2]:47 500 BC – Bian Que becomes the earliest physician known to use acupuncture and pulse diagnosis 500 BC – the Sushruta Samhita is published, laying the framework for Ayurvedic medicine 510-430 BC - Alcmaeon of Croton scientific anatomic dissections. He studied the optic nerves and the brain, arguing that the brain was the seat of the senses and intelligence. He distinguished veins from the arteries and had at least vague understanding of the circulation of the blood.[2] Variously described by modern scholars as Father of Anatomy; Father of Physiology; Father of Embryology; Father of Psychology; Creator of Psychiatry; Founder of Gynecology; and as the Father of Medicine itself.[5] There is little evidence to support the claims but he is, nonetheless, important.[6][7] c.484 – 425 BC Herodotus tells us Egyptian doctors were specialists: Medicine is practiced among them on a plan of separation; each physician treats a single disorder, and no more. Thus the country swarms with medical practitioners, some undertaking to cure diseases of the eye, others of the head, others again of the teeth, others of the intestines,and some those which are not local.[2] 496-405 BC - Sophocles “It is not a learned physician who sings incantations over pains which should be cured by cutting.”[8] 420 BC – Hippocrates of Cos maintains that diseases have natural causes and puts forth the Hippocratic Oath. Origin of rational medicine. c. 400 BC - 1 BC – The Huangdi Neijing (Yellow Emperor's Classic of Internal Medicine) is published, laying the framework for traditional Chinese medicine 4th century BC - Philistion of Locri[6] Praxagoras distinguishes veins and arteries and determines only arteries pulse[9] 375-295 BC Diocles of Carystus[1][6][10] 354 BC - Critobulus, extracts an arrow from Phillip II's eye, treating the loss of the eyeball without causing facial disfigurement 3rd century BC - Philinus of Cos founder of the Empiricist school. Herophilos and Erasistratus practice androtomy. (Dissecting live and dead human beings) 280 BC – Herophilus Dissection[7] studies the nervous system and distinguishes between sensory nerves and motor nerves and the brain. also the anatomy of the eye and medical terminology such as (in Latin translation "net like" becomes retiform/retina.[6] 270 – Huangfu Mi writes the Zhenjiu Jiayijing (The ABC Compendium of Acupuncture), the first textbook focusing solely on acupuncture 250 BC – Erasistratus studies the brain and distinguishes between the cerebrum and cerebellum physiology of the brain, heart and eyes, and in the vascular, nervous, respiratory and reproductive systems. 219 – Zhang Zhongjing publishes Shang Han Lun (On Cold Disease Damage). 200 BC – the Charaka Samhita uses a rational approach to the causes and cure of disease and uses objective methods of clinical examination 124- 44 BC - Asclepiades of Bithynia[7] 1st century AD - Rufus of Ephesus; Marcellinus a physician of the first century AD;[6] Numisianus[5] 23 AD – 79 AD Pliny the Elder ca 25 BC - ca 50 AD Aulus Cornelius Celsus Medical encyclopedia 50-70 AD – Pedanius Dioscorides writes De Materia Medica – a precursor of modern pharmacopoeias that was in use for almost 1600 years 2nd century AD Aretaeus of Cappadocia[7] 98-138 AD - Soranus of Ephesus[11] 129 - 216 AD – Galen Clinical medicine based on observation and experience.[10] The resulting tightly integrated and comprehensive system, offering a complete medical philosophy dominated medicine throughout the Middle Ages and until the beginning of the modern era.[12] After Galen 200 AD Main article: Medieval medicine d.260 - Gargilius Martialis, short Latin handbook on Medicines from Vegetables and Fruits[10] 4th century Magnus of Nisibis, Alexandrian doctor and professor book on urine[13] 325-400 - Oribasius 70 volume encyclopedia[3] 362 - Julian orders xenones built, imitating Christian charity (proto hospitals)[13] 369 Basil of Caesarea founded at Caesarea in Cappadocia an institution (hospital) called Basilias, with several buildings for patients, nurses, physicians, workshops, and schools[11] 375 - Ephrem the Syrian opened a hospital at Edessa[11] They spread out ans specialized nosocomia for the sick, brephotrophia for foundlings, orphanotrophia for orphans, ptochia for the poor, xenodochia for poor or infirm pilgrims, and gerontochia for the old.[11] 400 - The first hospital in Latin Christendom was founded by Fabiola at Rome[11] 420 - Caelius Aurelianus a doctor from Sicca Veneria (El-Kef, Tunisia) handbook On Acute and Chronic Diseases in Latin.[10] 447 - Cassius Felix of Cirta (Constantine, Ksantina, Algeria), medical handbook drew on Greek sources, Methodist and Galenist in Latin[10] 480 -547 Benedict of Nursia founder of "monastic medicine"[14] fl. 511–534 Anthimus Greek: Ἄνθιμος[15] 536 Sergius of Reshaina (died 536) A Christian theologian-physician who translated thirty-two of Galen’s works into Syriac and wrote medical treatises of his own[16] 525-605 - Alexander of Tralles[13] Alexander Trallianus 500-550 - Aetius of Amida Encyclopedia 4 books each divided into 4 sections[3][3][13] second half of 6th century building of xenodocheions/bimārestāns by the Nestorians under the Sasanians, would evolve into the complex secular “Islamic hospital,” which combined lay practice and Galenic teaching[16] 550-630 Stephanus of Athens[10][17] 560 – 636 Isidore of Seville c. 630 - Paul of Aegina Encyclopedia in 7 books very detailed surgery used by Albucasis[10][13][18] 790-869 Leo Itrosophist also Mathematician or Philosopher wrote "Epitome of Medicine" c. 800–873 – Al-Kindi (Alkindus) De Gradibus 820 - Benedictine hospital founded, School of Salerno would grow around it[3] 857d - Mesue the elder (Yūḥannā ibn Māsawayh) Syriac Christian[12] c. 830–870 – Hunayn ibn Ishaq (Johannitius) Syriac-speaking Christian also knew Greek and Arabic. Translator and author of several medical tracts.[12] c. 838–870 – Ali ibn Sahl Rabban al-Tabari, writes an encyclopedia of medicine in Arabic.[19] c.910d - Ishaq ibn Hunayn 9th century Yahya ibn Sarafyun a Syriac physician Johannes Serapion,[12] Serapion the Elder c. 865–925 – Rhazes pediatrics,[3][20] and makes the first clear distinction between smallpox and measles in his al-Hawi. d.955 - Isaac Judaeus Isḥāq ibn Sulaymān al-Isrāʾīlī Egyptian born Jewish physician[12] 913-982 - Shabbethai Donnolo alleged founding father of School of Salerno wrote in Hebrew[21] d. 982-994 'Ali ibn al-'Abbas al-Majusi Haly Abbas[3] 1000 – Albucasis (936-1018) surgery Kitab al-Tasrif, surgical instruments.[12] d.1075 - Ibn Butlan Christian physician of Baghdad Tacuinum sanitatis the Arabic original and most of the Latin copies, are in tabular format[12] 1018-1087 Michael Psellos or Psellus a Byzantine monk, writer, philosopher, politician and historian. several books on medicine[13] c. 1030 – Avicenna The Canon of Medicine The Canon remains a standard textbook in Muslim and European universities until the 18th century. c.1071-1078 Simeon Seth or Symeon Seth an 11th-century Jewish Byzantine translated Arabic works into Greek[13] 1084 - First documented hospital in England Canterbury[11] 1087d - Constantine the African[12] 1083-1153 Anna Komnene, Latinized as Comnena 1095 - Congregation of the Antonines, was founded to treat victims of "St. Anthony's fire" a skin disease.[11] late 11th early 12th century Trotula[22] 1123 - St Bartholomew's Hospital founded by the court jester Rahere Augustine nuns originally cared for the patients. Mental patients were accepted along with others[23] 1127 - Stephen of Antioch translated the work of Haly Abbas 1100–1161 – Avenzoar Teacher of Averroes[24] 1170 Rogerius Salernitanus composed his Chirurgia also known as The Surgery of Roger 1126-1198 - Averroes[3] c.1161d - Matthaeus Platearius 1204 - Innocent III organized the hospital of Santo Spirito at Rome inspiring others all over Europe c.1210-1277 - William of Saliceto also known as Guilielmus de Saliceto 1240 Bartholomeus Anglicus 1242 – Ibn an-Nafis suggests that the right and left ventricles of the heart are separate and discovers the pulmonary circulation and coronary circulation[12] c. 1248 – Ibn al-Baitar wrote on botany and pharmacy,[12] studied animal anatomy and medicine veterinary medicine. 1249 – Roger Bacon writes about convex lens spectacles for treating long-sightedness 1257 - 1316 Pietro d'Abano also known as Petrus De Apono or Aponensis[25] 1260 - Louis IX established, Les Quinze-vingt; originally a retreat for the blind, it became a hospital for eye diseases, and is now one of the most important medical centers in Paris[11] c. 1260 – 1316 Henri de Mondeville 1284 - Mansur hospital of Cairo[3] c. 1275 – c. 1328 Joannes Zacharias Actuarius a Byzantine physician wrote the last great compendium of Byzantine medicine[13] 1275-1326 Mondino de Luzzi "Mundinus" carried out the first systematic human dissections since Herophilus of Chalcedon and Erasistratus of Ceos 1500 years earlier.[26][27] 1300 – concave lens spectacles to treat myopia developed in Italy.[28] 1292-1350 - Ibn Qayyim al-Jawziya[3] 1306-1390 John of Arderne[26][29][30] d.1368 Guy de Chauliac[26][31] f.1460 Heinrich von Pfolspeundt[26][27][32][33][34] 1443-1502 Antonio Benivieni[26][35] Pathological anatomy[36] 1493-1541 Paracelsus[26] On the relationship between medicine and surgery[37] surgery book[38] 1500–1800 early 16th century: Paracelsus, an alchemist by trade, rejects occultism and pioneers the use of chemicals and minerals in medicine. Burns the books of Avicenna, Galen and Hippocrates.[39] Hieronymus Fabricius[26] His "Surgery" is mostly that of Celsus, Paul of Aegina, and Abulcasis citeing them by name.[40] Caspar Stromayr or Stromayer Sixteenth Century[26][41] 1500?-1561 Pierre Franco[26][34][42][43] Ambroise Pare 1510-1590 pioneered the treatment of gunshot wounds.[26][44][45] Bartholomeo Maggi at Bologna, Felix Wurtz of Zurich, Léonard Botal in Paris, and the Englishman Thomas Gale (surgeon), (the diversity of their geographical origins attests to the widespread interest of surgeons in the problem), all published works urging similar treatment to Paré’s. But it was Paré’s writings which were the most influential.[46] 1518 - College of Physicians founded now known as Royal College of Physicians of London is a British professional body of doctors of general medicine and its subspecialties. It received the royal charter in 1518[47] 1510-1590 Ambroise Paré surgeon[47] 1540-1604 William Clowes (surgeon)[26][33][48] Surgical chest for military surgeons[48][49] 1543 – Andreas Vesalius publishes De Fabrica Corporis Humani which corrects Greek medical errors and revolutionizes European medicine 1546 – Girolamo Fracastoro proposes that epidemic diseases are caused by transferable seedlike entities 1550-1612 Peter Lowe [26][49][50] 1553 – Miguel Serveto describes the circulation of blood through the lungs. He is accused of heresy and burned at the stake 1556 – Amato Lusitano describes venous valves in the Ázigos vein 1559 – Realdo Colombo describes the circulation of blood through the lungs in detail 1563 – Garcia de Orta founds tropical medicine with his treatise on Indian diseases and treatments 1596 – Li Shizhen publishes Běncǎo Gāngmù or Compendium of Materia Medica 1603 – Girolamo Fabrici studies leg veins and notices that they have valves which allow blood to flow only toward the heart 1621-1676 Richard Wiseman [26][33][49][51][52] 1628 – William Harvey explains the circulatory system in Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus 1683-1758 Lorenz Heister[26][49][53] 1688-1752 William Cheselden[26][49][54][55][56] 1701 – Giacomo Pylarini gives the first smallpox inoculations in Europe. They were widely practised in the east before then. 1714-1789 Percivall Pott[26][57][58][59][60] 1720 - Lady Mary Wortley Montagu 1728-1793 John Hunter (surgeon)[26][44][61][62] 1736 – Claudius Aymand performs the first successful appendectomy 1744-1795 Pierre-Joseph Desault[26][49][63] First surgical periodical[64] 1747 – James Lind discovers that citrus fruits prevent scurvy 1749-1806 Benjamin Bell Leading surgeon of his time and father of a surgical dynasty[26] system of surgery[65] 1752-1832 Antonio Scarpa[26][49][66][67] 1763-1820John Bell (surgeon)[26][33][68][69] 1766-1842 Dominique Jean Larrey Surgeon to Napoleon[26][33][49][70][71][72][73] 1768-1843 Astley Cooper sergeon[26][49][66] lectures[74] principles and practice[75] 1774-1842 Charles Bell, surgeon[26][33][68][76] 1774 – Joseph Priestley discovers nitrous oxide, nitric oxide, ammonia, hydrogen chloride and oxygen 1777-1835 - Baron Guillaume Dupuytren[26] Head surgeon at Hôtel-Dieu de Paris,[77] The age Dupuytren[78][79] 1785 – William Withering publishes "An Account of the Foxglove" the first systematic description of digitalis in treating dropsy 1790 – Samuel Hahnemann rages against the prevalent practice of bloodletting as a universal cure and founds homeopathy 1796 – Edward Jenner develops a smallpox vaccination method 1799 – Humphry Davy discovers the anesthetic properties of nitrous oxide 1800–1899 1800 – Humphry Davy announces the anaesthetic properties of nitrous oxide 1813-1883 James Marion Sims Vesico-vaganial surgery[26][80][81] Father of surgical genocology[33] Biography[82] 1816 – Rene Laennec invents the stethoscope 1827-1912 Joseph Lister Anti-septic surgery[26][49][83] Father of modern surgery[84] 1818 – James Blundell performs the first successful human blood transfusion 1842 – Crawford Long performs the first surgical operation using anesthesia with ether 1846 – First painless surgery with general anesthetic 1847 – Ignaz Semmelweis discovers how to prevent puerperal fever 1849 – Elizabeth Blackwell is the first woman to gain a medical degree 1867 – Lister publishes Antiseptic Principle of the Practice of Surgery, based partly on Pasteur's work 1870 – Louis Pasteur and Robert Koch establish the germ theory of disease 1878 – Ellis Reynolds Shipp graduates from Woman’s Medical College of Pennsylvania and begins practice in Utah 1879 – First vaccine for cholera 1881 – Louis Pasteur develops an anthrax vaccine 1882 – Louis Pasteur develops a rabies vaccine 1890 – Emil von Behring discovers antitoxins and uses them to develop tetanus and diphtheria vaccines 1895 – Wilhelm Conrad Röntgen discovers medical use of X-rays in medical imaging 1900–1999 1901 – Karl Landsteiner discovers the existence of different human blood types 1901 – Alois Alzheimer identifies the first case of what becomes known as Alzheimer's disease 1903 - Willem Einthoven discovers electrocardiography (ECG/EKG) 1906 – Frederick Hopkins suggests the existence of vitamins and suggests that a lack of vitamins causes scurvy and rickets 1907 – Paul Ehrlich develops a chemotherapeutic cure for sleeping sickness 1908 – Victor Horsley and R. Clarke invents the stereotactic method 1909 – First Intrauterine device described by Richard Richter.[85] 1910 - Hans Christian Jacobaeus performs the first laparoscopy on humans 1917 – Julius Wagner-Jauregg discovers the malarial fever shock therapy for general paresis of the insane 1921 – Edward Mellanby discovers vitamin D and shows that its absence causes rickets 1921 – Frederick Banting and Charles Best discover insulin – important for the treatment of diabetes 1921 – Fidel Pagés pioneers epidural anesthesia 1923 – First vaccine for Diphtheria 1926 – First vaccine for Pertussis 1927 – First vaccine for Tuberculosis 1927 – First vaccine for Tetanus 1928 – Alexander Fleming discovers penicillin 1929 – Hans Berger discovers human electroencephalography 1932 – Gerhard Domagk develops a chemotherapeutic cure for streptococcus 1933 – Manfred Sakel discovers insulin shock therapy 1935 – Ladislas J. Meduna discovers metrazol shock therapy 1935 – First vaccine for Yellow Fever 1936 – Egas Moniz discovers prefrontal lobotomy for treating mental diseases; Enrique Finochietto develops the now ubiquitous self-retaining thoracic retractor 1938 – Ugo Cerletti and Lucio Bini discover electroconvulsive therapy 1943 – Willem J Kolff build the first dialysis machine 1944 - Disposable Catheter - David S. Sheridan 1946 - Chemotherapy - Alfred G. Gilman and Louis S.Goodman 1947 - Defibrillator - Claude Beck 1948 - Acetaminophen - Julius Axelrod, Bernard Brodie 1949 – First implant of intraocular lens, by Sir Harold Ridley 1949 - mechanical assistor for anesthesia - John Emerson 1952 – Jonas Salk develops the first polio vaccine (available in 1955) 1952 - Cloning - Robert Briggs & Thomas King 1953 - Heart-Lung Machine - Dr John Heysham Gibbon 1953 - Medical Ultrasonography - Inge Edler 1954 - Joseph Murray performs the first human kidney transplant (on identical twins) 1954 - Ventouse - Tage Malmstrom 1955 - Tetracycline - Lloyd Conover 1956 - Metered Dose Inhaler - 3M 1957 – William Grey Walter invents the brain EEG topography (toposcope) 1958 - Pacemaker - Rune Elmqvist 1959 - In Vitro Fertilization - Min Chueh Chang 1960 – Invention of Cardiopulmonary resuscitation (CPR) 1960 – First combined oral contraceptive approved by the FDA[85] 1962 - Hip Replacement - John Charnley 1962 - Beta Blocker James W. Black 1962 – First Oral Polio Vaccine (Sabin) 1963 - Artificial Heart - Paul Winchell 1963 - Thomas Starzl performs the first human liver transplant 1963 - James Hardy performs the first human lung transplant 1963 - Valium (diazepam) - Leo H Sternbach 1964 – First vaccine for Measles 1965 – Frank Pantridge installs the first portable defibrillator 1965 – First commercial ultrasound 1966 - C. Walton Lillehei performs the first human pancreas transplant 1966 - Rubella Vaccine - Harry Martin Meyer and Paul D. Parkman[86] 1967 – First vaccine for Mumps 1967 – Christiaan Barnard performs the first human heart transplant 1968 - Powered Prothesis - Samuel Alderson 1968 - Controlled Drug Delivery - Alejandro Zaffaron 1969 - Internet - Advanced Research Project Agency (ARPA) 1969 - Balloon Catheter - Thomas Fogarty 1969 - Cochlear Implant - William House 1970 - Cyclosporine, the first effective immunosuppressive drug is introduced in organ transplant practice 1971 - Genetically Modified Organisms - Ananda Chakrabart 1971 - Magnetic Resonance Imaging - Raymond Vahan Damadian 1971 - Computed Tomography (CT or CAT Scan) - Godfrey Hounsfield 1971 - Transdermal Patches - Alejandro Zaffaroni 1971 – Sir Godfrey Hounsfield invents the first commercial CT scanner 1972 - Insulin Pump - Dean Kamen 1973 - Laser Eye Surgery (LASIK) - Mani Lal Bhaumik 1974 - Liposuction - Giorgio Fischer 1976 – First commercial PET scanner 1978 – Last fatal case of smallpox[87] 1979 Antiviral Drugs - George Hitchings & Gertrude Elion 1980 – Raymond Damadian builds first commercial MRI scanner 1980 - Lithotripter - Dornier Research Group 1980 – First vaccine for Hepatitis B - Dr Baruch Samuel Blumberg 1981 - Artificial Skin - John F. Burke & Ioannis V Yannas 1981 - Bruce Reitz performs the first human heart-lung combined transplant 1982 - Humulin insulin - Eli Lilly Interferon Cloning - Sidney Pestka 1985 - Automated DNA Sequencer - Leroy Hood & Lloyd Smith 1985 - Polymerase Chain Reaction (PCR) - Kaery Mullis 1985 - Surgical Robot - Dr Yik San Kwoh 1985 - DNA Fingerprinting - Alec Jeffreys 1985 - Capsule Endoscopy - Tarun Mullick 1986 - Fluoxetine HCl - Eli Lilly and Co 1987 – Ben Carson, leading a 70-member medical team in Germany, was the first to separate occipital craniopagus twins. 1987 - commercially available Statins - Merck & Co. 1987 - Tissue Engineering - Joseph Vacanti & Robert Langer 1988 - Intravascular Stent - Julio Palmaz 1988 - Laser Cataract Surgery - Dr Patricia Bath 1989 - Pre-implantation Genetic Diagnosis (PGD) - Alan Handyside 1989 - DNA Microarray - Stephen Fodor 1990 - Gamow Bag ® - Dr Igor Gamow 1992 – First vaccine for Hepatitis A available[88] 1992 - Electroactive Polymer (Artificial Muscle) - SRI International 1992 - Intracytoplasmic Sperm Injection (ICSI) - Andre van Steirteghem 1996 - Dolly the Sheep cloned 1998 - Stem Cell Therapy - James Thomson humps 2000 – present Further information: 21st century#Medicine See also: Medicine in the 2010s 26 June 2000 - Human Genome draft completed 2001 Telesurgery - Jacques Marescaux 2001 Artificial liver - Kenneth Matsumura 2003 – Carlo Urbani, of Doctors without Borders alerted the World Health Organization to the threat of the SARS virus, triggering the most effective response to an epidemic in history. Urbani succumbs to the disease himself in less than a month. 2005 – Jean-Michel Dubernard performs the first partial face transplant 2006 – First HPV vaccine approved 2006 – Second rotavirus vaccine approved (first was withdrawn) 2007 - Visual prosthetic (bionic eye) Argus II 2008 – Laurent Lantieri performs the first full face transplant 2013 - First kidney grown in vitro in the U.S. 2013 - First human liver grown from stem cells in Japan |
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