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Skondia's nootropic criteria: I. No direct vasoactivity A. No vasodilation B. No vasoconstriction II. EEG activity: No change in basic rhythm A. Quantitative EEG: Increased power spectrum (beta 2 and alpha) B. Qualitative EEG: Decreased delta waves and cerebral suffering III. Must pass blood-brain barrier A. Under normal conditions B. Under pathological conditions IV. Must show metabolic activity in: A. Animal brain metabolism 1. Molecular 2. Physiopathological B. Human brain metabolism (clinical evaluation) 1. A-V differences a. Increased extraction quotients of O2 b. Increased extraction quotients of glucose c. Reduced lactate pyruvate ratio 2. Regional cerebral metabolic rates (rCMR) a. Increased ICMR of O2 b. Increased rCMR of glucose 3. Regional cerebral blood flow: Normalization V. Minimal side effects VI. Clinical trials must be conducted with several rating scales designed to objectify metabolic cerebral improvement. |
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