Less blood glucose means less glycation of adjacent proteins and less fat to oxidize in the bloodstream to cause sticky blocks resulting in atherosclerosis. Type 2 diabetics are people with insulin insensitivity caused by long-term exposure to high blood glucose. Obesity leads to type 2 diabetes. Type 2 diabetes and uncontrolled type 1 diabetes are much like "accelerated aging", due to the above effects. There may even be a continuum between CR and the metabolic syndrome. Caloric restriction with optimal nutrition has not been tested in comparison to caloric excess with optimal nutrition. It may be that with extra calories, nutrition must be similarly increased to ratios comparable to that of calorie restriction in order to provide similar anti-aging benefits. Stated levels of calorie needs may be biased towards sedentary individuals. Calorie restriction may be nothing other than adapting the diet to the body's needs. |
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